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First purported images of ciguatoxin-3C by cryogenic and transmission electron microscopy
Ciguatera poisoning is the most commonly reported non-bacterial seafood-related illness worldwide and is caused by the consumption of fish or shellfish containing ciguatoxins (CTXs). Reliable laboratory testing in clinical samples for CTXs is not available. Herein, the first purported images of CTX-3C obtained by Cryogenic Electron Microscopy (Cryo-EM) and in the presence of gold nanoparticles with attached antibodies by Transmission Electron Microscopy (TEM) are presented. The authors discuss how other existing instrumentations with atomic resolutions could be applied. Conventional detection methods for marine toxins have drawbacks, applying cutting-edge existing technologies such as TEMs to directly observe never-before-seen marine toxins can contribute to the fundamental science of marine toxins research.
The article was published in the "Journal of Molecular Structure".
First purported images of ciguatoxin-3C by cryogenic and transmission electron microscopy
Christopher R. Loeffler, Ashish Gadicherla
Journal of Molecular Structure
Volume 1296, Part 1
2024
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